The most modern looking UI available at this moment has to be MacOS, but applications like Google's Picasa also have a quite similar feel to them. Now that we're on the final straight before Vista comes along and makes Windows look different the question becomes what is it about these UIs that makes them so different?
The most obvious is that a lot more colours are used, and there are gradients everywhere. Icons also become more colourful and detailed of course, with a more photo realistic style being used for things like recyle/trash bins and drives. This, of course, is a...